Amphotericin B is well established as a fungistatic agent1 that is effective in the treatment of several systemic mycotic infections.2 Experience with its use in fungus diseases of the eye, though apparently beneficial, has been limited.3-6 Two reports have been found in which amphotericin B was used in the treatment of postoperative mycotic intraocular infections.5,6Whether amphotericin B penetrates the eye is unknown. Previous attempts to demonstrate such penetrations have been unsuccessful,3 and it has been stated that amphotericin B cannot be identified in intraocular fluids following parenteral administration.4Recently a patient with postoperative mycotic endophthalmitis was observed in whom the use of intravenous amphotericin B resulted in a dramatic response with clearing of the infection. The clinical observation prompted laboratory studies of the intraocular penetration of amphotericin B in rabbits under experimental conditions.
A 75-year-old white woman was first found
GREEN WR, BENNETT JE, GOOS RD. Ocular Penetration of Amphotericin BA Report of Laboratory Studies and a Case Report of Postsurgical Cephalosporium Endophthalmitis. Arch Ophthalmol. 1965;73(6):769-775. doi:10.1001/archopht.1965.00970030771004