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To the Editor:
It is clear that Dr. Mueller and Mr. Trevor-Roper (Arch Ophthal 72:741-742, 1964) in their studies based on the early work of Dr. Aubrey Smith have demonstrated the possibility of freezing corneas and preserving some tissue viability. General procedures for the preservation of many types of tissue, however, have been known for a long time. In order for this technique to be maximally useful, the frozen tissue must be as good, or nearly as good as fresh tissue, and a guide to the quantitative degree of success of the preservation procedure has been lacking. The clinical usefulness of preserved corneal tissue will depend on the comparability of frozen tissue and fresh tissue, not only in favorable cases in which the recipient's endothelium is healthy and can heal over large defects, but in cases of endothelial dystrophy in which the donor's endothelium must persist and defects in the
Kaufman HE. PRESERVING CORNEAS BY FREEZING. Arch Ophthalmol. 1965;73(6):907-908. doi:10.1001/archopht.1965.00970030909029