The interest in the so-called retinal circulation time is only of very recent date. Following the reports by Flocks and coworkers in 19581 and 19592 on cats, the first study on human retinal circulation time was published by Suvanto et al3 from Finland in 1960. Besides several papers on fluorescein fundus photography4,5 the only other studies pertaining specifically to human retinal circulation time were reported by Hart et al6,7 in 1963 and recently by Ferrer.8 The Finnish group used intracarotid injection of Evans blue, ophthalmoscope, and stop watch. The Duke University group worked with intravenous fluorescein and fundus movies, and Ferrer was able to obtain still photos with flash exposures every second. The former group found one to two seconds for the retinal circulation time, the latter investigators an average of five seconds.
For the present study a technique similar to that described
OBERHOFF P, EVANS PY, DELANEY JF. Cinematographic Documentation of Retinal Circulation Times. Arch Ophthalmol. 1965;74(1):77-80. doi:10.1001/archopht.1965.00970040079019