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Dr. Castroviejo's letter was referred to Dr. Scheie who offers the following reply.
To the Editor:
Dr. Castroviejo has commented in a very intelligent and practical way on the paper, "Ophthalmic Ointment Bases in the Anterior Chamber," by Scheie, Rubenstein, and Katowitz. We find ourselves in general agreement with opinions he has expressed. We agree that drugs contained in an ointment base are more effective than when in aqueous solution.However, after considerable animal experimentation and observation upon two patients, we are convinced that oily substances, particularly lanolin, can be injurious to the eye when placed in the anterior chamber. Although 19 years have passed since peanut oil accidentally contaminated the anterior chamber of our first patient, it still remains and is fixed in the upper angle where it is causing slight edema of the overlying cornea and could eventually lead to dystrophy.Therefore, we feel that the instillation of
Scheie HG. OINTMENT BASES IN THE ANTERIOR CHAMBER-Reply. Arch Ophthalmol. 1965;74(1):143-144. doi:10.1001/archopht.1965.00970040145035