[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 50.16.79.246. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
August 1965

Myasthenia GravisA Review of the Disease and a Description of Lid Twitch as a Characteristic Sign

Author Affiliations

Boston
From the Howe Laboratory of Ophthalmology, Harvard University Medical School, Massachusetts Eye and Ear Infirmary.

Arch Ophthalmol. 1965;74(2):217-221. doi:10.1001/archopht.1965.00970040219016
Abstract

Our concept of myasthenia gravis has evolved from: (1) its recognition as a clinical syndrome first enunciated by T. Willis in the 17th century1; (2) its more precise exposition by Erb in 1879 and by Goldflam in 18931 (whence the designation Erb-Goldflam disease); (3) an effective treatment by anticholinesterase agents introduced by Walker in 19342; (4) its pharmacodiagnosis by means of intramuscular neostigmine (Prostigmine), described by Viets and Schwab in 1935,3 improved later by the use of intravenous edrophonium chloride (Tensilon)4; (5) its curious association with thymic hyperplasia and sometimes with thymomas5,6; (6) a significantly frequent association of a myasthenic syndrome with dysthyroidism, bronchogenic carcinoma,7 and with some of the autoimmune diseases8; and (7) a characteristic fatigue pattern demonstrable by electromyography, which may be of diagnostic significance.9

The extraocular muscles and orbicularis oculi are the muscles most commonly affected. Approximately half

First Page Preview View Large
First page PDF preview
First page PDF preview
×