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September 1965

Treatment of Experimental Fungal Keratitis

Author Affiliations

St. Louis
From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine. Department of Ophthalmology (Dr. Berson and Dr. Oglesby); Department of Internal Medicine, Division of Dermatology (Dr. Kobayashi).

Arch Ophthalmol. 1965;74(3):403-411. doi:10.1001/archopht.1965.00970040405022

Several excellent reviews10,11,26,39,42 and case reports4,5,21,24,27 have emphasized the difficulty in treatment of mycotic keratitis and the aggravating effects of some antibiotics20,33,41 and steroids1,4,20,28,40 on these infections. The various forms of chemotherapy have included amphotericin B with debridement,4,5,13 30% sodium sulfacetamide solution by iontophoresis,13 1:1,000 Merthiolate ophthalmic ointment,13 nystatin topically,9,31 local cycloheximide,23 and oral sodium iodide with local 0.125% copper sulfate and tincture of iodine.2,6 Poor intraocular penetration29 and local toxicity1 of the suggested drugs have hampered interpretation of chemotherapy. Physical measures suggested for treatment have included ultraviolet phototherapy,7 thermophore,2 and excision with keratoplasty.42 Human clinical experience has been difficult to evaluate because the stage of the disease at the time of treatment has varied and the fungus has differed from case to case. The number of cases reported by any single study has been

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