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October 1965

Immunization of Rabbits With Autologous Lens Homogenates

Author Affiliations

Bari, Italy
From the Department of Ophthalmology, University of Bari; Director: Prof Franco D'Ermo.

Arch Ophthalmol. 1965;74(4):528-531. doi:10.1001/archopht.1965.00970040530017

The involvement of autoimmune processes in certain ophthalmologic diseases has long been discussed by many investigators. Recently, D'Ermo1 has further stressed the potential importance of autoimmune phenomena in pathological conditions of the lens.

It is generally agreed that the injection of heterologous or homologous lens extracts evokes the production of circulating antibodies, a conclusion which has been extensively documented in the recent review of Halbert and Mansky.2 However, the demonstration of antibody formation following the injection of autologous lens antigens is less readily achieved.

Müller3 reported that simple trauma of the lens in rabbits induced an immune response, but these results were not confirmed in the experiments of Lyda and Lippincott.4 However Uhlenhuth and Händel5 also succeeded in demonstrating autoimmunization of guinea pigs with lens material. More recently Hackett and Thompson6 detected antibodies to lens extracts in the sera of many healthy humans, and

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