The prime purpose of this study has been to explore new means of provoking closure of the anterior chamber angle as a step in the search for the ideal provocative test for early detection of angle closure glaucoma.
It is known that in eyes which have had an attack of angle closure glaucoma and in the fellow eye the yield of positive results in the two standard clinical provocative tests (dark test and mydriatic provocative test) is less than 50% (Becker and Thompson3). Moreover, there are many patients in whom a highly suggestive history of angle closure has been followed by repeated provocative tests in all of which results have been negative. Not infrequently eyes from both of these groups have later developed angle closure, sometimes under unfavorable circumstances. Considering the low yield of positive cases when provocative tests capable of being performed by every ophthalmologist in his office
KIRSCH RE. A Study of Provocative Tests for Angle Closure Glaucoma. Arch Ophthalmol. 1965;74(6):770-776. doi:10.1001/archopht.1965.00970040772006