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Dr. Bedrossian's letter was referred to Dr. Howard. His reply follows:
To the Editor:
Dr. Bedrossian has performed a service by pointing out that a minimal amount of α-chymotrypsin suffices when used to facilitate cataract extraction, and that waiting more than two minutes for the enzyme to act on the zonules does not increase its effectiveness. There are some of us, however, who do not agree with his contention that it is unnecessary to irrigate the anterior chamber following the use of α-chymotrypsin.In the discussion which follows that paper by Drs. Bedrossian and Weimer (Trans Amer Acad Ophthal Otolaryng 67:822, 1963) there is an apt exposition of the technical objections to the omission of such irrigation by Dr. Bernard Schwartz. Briefly, several reports exist indicating that the proteolytic effects of α-chymotrypsin may be associated with such postoperative complications as delayed healing of corneoscleral section, hyphema, corneal dystrophy, and dissolution
Howard GM. IRRIGATION AFTER CHYMOTRYPSIN?-Reply. Arch Ophthalmol. 1965;74(6):883. doi:10.1001/archopht.1965.00970040884031