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A series of neurophysiologic investigations which have been proceeding in recent years could have important ophthalmic applications. Yet, for reasons which we are fearful to probe, few of them have been reported in the ophthalmic literature. These are the investigations which had their inception in Hartline's demonstrations of excitatory-inhibitory fibers in the optic nerve of the horseshoe crab, their development in Kuffler's investigations of on-center and off-center responses in ganglion cells of the cat retina, and their present development in Hubel and Wiesel's analysis of occipital cell function in the cat's and monkey's visual system.
All these experiments have been made possible by the availability of a technique for recording the electrical activity of individual neurons. This enabled Kuffler to find out that the spontaneous activity of an individual ganglion cell could be enhanced or inhibited by illuminating one spot on the retina and an opposite effect elicited by illuminating
C. D. Researches Into Vision. Arch Ophthalmol. 1966;75(2):155-156. doi:10.1001/archopht.1966.00970050157002