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The letter from Drs. Radnot and Farkas was referred to Dr. Bellows who offers the following reply:
To the Editor:
The question of sterility of cryogens has been frequently raised by ophthalmologists who use or intend to use cryosurgical techniques. This letter is submitted to settle this question. At the same time I should like to correct a misconception that may have been created by a statement in the article by Dr. R. D. Mattis et al, entitled Disposable Cryophake-Clinical Evaluation. (Arch Ophthal74:787, 1965) which reads as follows: "in neither case (referring to my solid CO2 and liquid N2 instruments) is the gas sterile." From this statement the uninformed reader may surmise that my instruments do not meet the aseptic requirements of modern surgery.Admittedly cryogens will not destroy pathogenic organisms if they cool very rapidly. The reason for this is that rapid freezing does not
Bellows JG. STERILITY AND CRYOSURGERY-Reply. Arch Ophthalmol. 1966;75(2):303-304. doi:10.1001/archopht.1966.00970050304032