The intraocular pressure is the force required to maintain aqueous flow. Normally it varies with the rate of aqueous formation and the resistance to outflow encountered at the trabecular meshwork. Additional outflow resistance may occur from various pathologic closures of the chamber angle including anterior displacement of the iris root. In primary angle closure glaucoma, the iris root is displaced forward without apparent cause, and the angle closure is usually associated with shallowing of the anterior chamber. This discussion is concerned solely with the pathogenesis of primary angle closure glaucoma associated with a shallow anterior chamber.
Clinically, this disease appears to be acquired since it almost always occurs after the fourth decade. It is characterized by a slow progressive shallowing of the anterior chamber which may antedate by several years rise in intraocular pressure. The pressure rise may be explosive, indicating that critical closure of the angle can
CHRISTENSEN L, IRVINE AR. Pathogenesis of Primary Shallow Chamber Angle Closure Glaucoma. Arch Ophthalmol. 1966;75(4):490-495. doi:10.1001/archopht.1966.00970050492009