[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 184.73.17.193. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
May 1966

Ocular Manifestations of Congenital Rubella SyndromeRecovery of Virus From Affected Infants

Author Affiliations

Memphis
From the departments of surgery (ophthalmology) and pediatrics of the University of Tennessee Medical Units, Memphis.

Arch Ophthalmol. 1966;75(5):601-607. doi:10.1001/archopht.1966.00970050603004
Abstract

The congenital rubella syndrome is a welldescribed clinical entity. Gregg of Australia in 1941 first described congenital malformations following maternal rubella cases.1 These defects included small, malnourished infants with unilateral or bilateral cataracts, sluggish pupillary response to light, nystagmus in the older babies, corneal haze that cleared, microphthalmus, heart lesions (usually patent ductus arteriosus), and an intolerance to atropine. This work was reviewed for the American ophthalmic literature by Reese in 1944.2

Charles Swan of Australia confirmed these observations in 1943 and also extended the spectrum to include deaf-mutism, cardiac defects without apparent ophthalmic defects, and microcephaly.3 Evans in 1944 first described tooth abnormalities consisting of retarded eruption and hypoplasia of the tooth enamel.4 Bruce Hamilton and associates5 in 1948 and Morlet6 in 1949 reported associated pigmentation of the retina in eyes without cataracts. Lundstrom in 1962 confirmed the above observations and found significant

First Page Preview View Large
First page PDF preview
First page PDF preview
×