A variety of substances are now used in treating open angle glaucoma; their comparative effectiveness needs further study. Pilocaprine has long been the standard beginning therapy for the early form of this disease. However, it has a maximum duration of action of only four to six hours, and its use results in poor control of ocular tensions part of the time.1,2 This is particularly true at night, when eight to ten hours may elapse between doses. Frequent use of drops, as is required with pilocarpine, is considered by many patients as a nuisance and a serious objection. The purpose of the study is to compare the effectiveness of pilocarpine with two long-acting medications: epinephrine and echothiophate iodide.
Epinephrine has been known to be effective in the treatment of glaucoma since the early 1900's, but it never achieved great popularity until it was reintroduced in the middle 1950's. It has
BLANTON FM, POLLACK IP. Therapy of Open Angle Glaucoma. Arch Ophthalmol. 1966;75(6):763-767. doi:10.1001/archopht.1966.00970050765009