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Article
July 1966

Experimental Glaucoma in MonkeysII. Studies of Intraocular Vascularity During Glaucoma

Author Affiliations

Miami, Fla
From the Bascom Palmer Eye Institute, University of Miami, School of Medicine, Miami, Fla.

Arch Ophthalmol. 1966;76(1):94-103. doi:10.1001/archopht.1966.03850010096018
Abstract

In the experiments described in the previous paper (Kalvin et al [1966],1 cupping of the optic disc and atrophy of the optic nerve were found after moderate to severe elevation of the intraocular pressure (>40 mm Hg) which lasted longer than 36 hours. Although evidence was obtained on the site of action of the α-chymotrypsin and on the conditions necessary to produce the optic nerve changes, still, the pathogenesis of these changes was not determined.

The following observations indicated that the changes could be related to alteration of the blood flow pattern to the glaucomatous eyes:

  1. The rapidity of development of the optic nerve changes.

  2. Macrohemorrhages and microhemorrhages in the optic disc, and in and around the optic nerve.

  3. Peripapillary retinal edema.

  4. Nasal displacement of the blood vessels on the optic disc.

  5. Engorgement of the retinal veins.

Thus, the present experiments were performed to

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