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Dr. Kaiser's letter was referred to Dr. Grant who offers the following reply:
To the Editor:
The very large literature on toxic effects of quinine on the eye seems to be composed almost entirely of case reports, carrying with them the implication that idiosyncracy to ordinary doses or poisoning by overdosage is involved. There are also reports of experimental work on animals.I know of no systematic evaluation of the influence of quinine in ordinary dosage on the retinal vessels in human beings by modern objective methods, such as standardized fundus photography.Dr. Kaiser's belief in a graded response rests on his undocumented impression and recollection, and differs from what is generally thought. However, it is an intriguing idea, which deserves further exploration.
Grant WM. QUININE IN THE TREATMENT OF DIABETIC RETINOPATHY-Reply. Arch Ophthalmol. 1966;76(1):158. doi:10.1001/archopht.1966.03850010160035