Various ocular abnormalities have been observed in patients with the Ehlers-Danlos syndrome (ED). In a review of personal cases McKusick1 found that epicanthal folds were the most common associated ocular abnormality. Other less frequent ocular changes occurring in this disease were strabismus,2-6 blue sclerotics,6-12 microcornea,9,13 myopia,6,13 keratoconus,11,12,14 ectopia lentis,11,15 hypertelorism,16 and intraocular hemorrhage.17 Bonnet7 described depigmentation in the preequatorial region of the fundus. Retinal detachment and retinitis proliferans in one eye, and macular degeneration in the other eye, were observed in a 19-year-old girl with ED.8 Angioid streaks were seen in patients who were affected with pseudoxanthoma elasticum and ED,4,18 but the occurrence of angioid streaks in patients with ED alone has not been reported, to our knowledge.
In the present paper the ocular changes observed in the Ehlers-Danlos syndrome will be described in 15 members of two
GREEN WR, FRIEDMAN-KIEN A, BANFIELD WG. Angioid Streaks in Ehlers-Danlos Syndrome. Arch Ophthalmol. 1966;76(2):197-204. doi:10.1001/archopht.1966.03850010199009