This study has outlined the rate and duration of penetration of tritiated prednisolone into the aqueous humor following a single clinical dose. The prednisolone labeled with tritium was incorporated into a commercial preparation. The concentration of drug reached a peak of 7.651μg/gm of aqueous humor at 30 minutes and decreased to a level of 2.176μg/gm at 240 minutes. These results are compared with the penetration of tritiated dexamethasone.
MURDICK PW, KEATES RH, DONOVAN EF, WYMAN M, SHORT C. Ocular Penetration StudiesII. Topical Administration of Prednisolone. Arch Ophthalmol. 1966;76(4):602-603. doi:10.1001/archopht.1966.03850010604023