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March 1967

Histogenesis of Malignant Melanomas of the UveaIII. The Relationship of Congenital Ocular Melanocytosis and Neurofibromatosis to Uveal Melanomas

Author Affiliations

Washington, DC
From the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC. Dr. Yanoff is presently with the departments of ophthalmology and pathology, Hospital of the University of Pennsylvania, Philadelphia.

Arch Ophthalmol. 1967;77(3):331-336. doi:10.1001/archopht.1967.00980020333007

Each of 12 malignant melanomas arising in eyes with congenital ocular melanocytosis and one arising in a patient with systemic and ocular neurofibromatosis contained nevus cells. The vast majority of malignant melanomas of the uvea, whether they arise in eyes with ocular melanocytosis, neurofibromatosis, or in otherwise normal eyes, appear to develop from preexisting nevi.