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April 1967

Ocular Pathology in the Rubella Syndrome

Author Affiliations

Houston; Washington, DC
From the Jefferson Davis, Ben Taub, and Texas Children's hospitals, and the departments of ophthalmology, pathology, and pediatrics, Baylor College of Medicine (Dr. Boniuk); and from the Armed Forces Institute of Pathology (Dr. Zimmerman).

Arch Ophthalmol. 1967;77(4):455-473. doi:10.1001/archopht.1967.00980020457008

THE RELATIONSHIP between congenital cataracts, deafness, cardiovascular malformations, and other abnormalities in infants born to mothers who have had rubella in the first trimester of pregnancy has been widely recognized since Gregg1 first described this association in 1941. Recent interest in the rubella syndrome has been due to the development of virologic techniques for the growth of rubella virus in tissue culture2,3 and to the widespread epidemic in the United States during the winter and spring of 1963 to 1964. There have been many older and several recent reports4,5 describing the ocular manifestations of the rubella syndrome. In the past, very few eyes have been examined pathologically, and little has been written regarding the pathologic changes in the eyes in the rubella syndrome. As a result of the recent epidemic, a fairly large number of eyes have become available for pathologic examination; the purpose of the present

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