IN 1955 Reese1 characterized persistent hyperplastic primary vitreous (PHPV) as a congenital condition that leads to enucleation in infancy or childhood because a retinoblastoma is suspected or because complications intrinsic to PHPV, such as intraocular hemorrhage, secondary glaucoma, or corneal opacification, have occurred. Rarely do eyes with PHPV escape enucleation during the first decade (Table). Reese followed only one of 60 cases from birth to the 14th year without complications, and he commented that he had never seen a recognizable case in an adult.
The discovery of PHPV in a 22-year-old woman prompted this report.
Report of a Case
—A 22-year-old white woman was seen two weeks prior to enucleation because of a painful right eye. The patient had been virtually blind in this eye since childhood and during the preceding year it had become intermittently painful.On the first examination the visual acuity of the right
Spaulding AG, Naumann G. Persistent Hyperplastic Primary Vitreous in an AdultA Brief Review of the Literature and a Histopathologic Study. Arch Ophthalmol. 1967;77(5):666-671. doi:10.1001/archopht.1967.00980020668019