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September 1967

Experimental Inclusion Conjunctivitis in ManIII. Keratitis and Other Complications

Author Affiliations

San Francisco
From the Francis I. Proctor Foundation for Research in Ophthalmology, and the Department of Microbiology, University of California San Francisco Medical Center, San Francisco.

Arch Ophthalmol. 1967;78(3):341-349. doi:10.1001/archopht.1967.00980030343015

Volunteers infected with inclusion conjunctivitis agent regularly developed keratitis in addition to acute follicular conjunctivitis. The corneal signs included epithelial keratitis, marginal and central subepithelial infiltrates, and focal neovascularization at the limbus. In reinfected volunteers, keratitis was no more frequent but appeared sooner than in initial infections. In three instances, anterior uveitis appeared during the course of experimental infections. In two volunteers this occurred in conjunction with the reactivations of conjunctival disease. Although there is considerable overlapping of the clinical signs of classic trachoma and inclusion conjunctivitis in adults, the two diseases should still be regarded as distinct clinical entities.