Injection of silastic under the anterior uvea in rabbits resulted in a decrease of ocular tension lasting for two to five months when one fourth to one half of the ciliary body was detached. The recovery pattern showed a characteristically gradual, exponential rise of tension. Detachment of an equal amount of anterior choroid resulted in hypotony for one month, with a much steeper recovery curve. The histological findings and recovery course suggest that these implants cause hypotony by their traumatic effects rather than by the detachment space they create. The clinical implications of these results and of several operative complications are discussed.
Streeten BW, Belkowitz M. Experimental Hypotony With Silastic. Arch Ophthalmol. 1967;78(4):503-511. doi:10.1001/archopht.1967.00980030505018