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To the Editor.
—A 20-year-old male college student with known low-grade Gilbert's disease, but without demonstrable jaundice, was seen on Dec 31, 1966, with a one-year history of change in central vision. The history was unclear, but he did admit to using lysergic acid diethylamide (LSD) on five or six occasions. He had no recollection of staring into the sun at these times. He had once smoked but had given this up before I saw him. He was myopic (OD -1.75, OS -1.00) and saw 20/40 and 20/60 corrected. He presented on Dec 31, 1966, a good foveal reflex on the right surrounded by vague drusen-like bodies. The left macula was edematous with similar white "dots." Vitreous cells were never seen.He was treated with prednisone, initial doses of 40 mg daily. The edema cleared but vision worsened to 20/60 and 20/100+ (corrected) by June 9, 1967. The final picture
Gordon DM. VISUAL DEFECTS AND LSD. Arch Ophthalmol. 1967;78(4):563-564. doi:10.1001/archopht.1967.00980030565025