Mannitol administered intravenously produced a severe reaction resembling anaphylaxis in a healthy 65-year-old woman with glaucoma and a positive allergic history, who had never knowingly received the medication before. Skin testing suggested an immediate-type hypersensitivity of the patient to mannitol. Since mannitol is an important component of most fungi it is possible that the initial sensitizing episode occurred 40 years previously when the patient received "allergy shots."
Spaeth GL, Spaeth EB, Spaeth PG, Lucier AC. Anaphylactic Reaction to Mannitol. Arch Ophthalmol. 1967;78(5):583-584. doi:10.1001/archopht.1967.00980030585004