A 64-year-old woman had complete external ophthalmoplegia secondary to systemic amyloidosis documented by a submaxillary gland biopsy, a skin biopsy, and multiple organ involvement (heart, rectum, vagina, kidneys, adrenal and thyroid glands). Amyloid was present in conjunctiva, orbital fat, and extraocular muscle.
Macoul KL, Winter FC. External OphthalmoplegiaSecondary to Systemic Amyloidosis. Arch Ophthalmol. 1968;79(2):182-184. doi:10.1001/archopht.1968.03850040184015