[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
March 1968

An Experimental Study of Dichloroethane Poisoning

Author Affiliations

From Howe Laboratory of Ophthalmology, Harvard University Medical School, Massachusetts Eye and Ear Infirmary, Boston.

Arch Ophthalmol. 1968;79(3):321-330. doi:10.1001/archopht.1968.03850040323018

Systemic administration of 1, 2-dichloroethane causes corneal clouding specifically in the dog, but its lethality is approximately equivalent in dogs, cats, rabbits, and rats. In contrast to the ocular effects on systemic administration, injection of dichloroethane into the anterior chamber is equally toxic to the corneas of dogs, cats, and rabbits. The characteristic abnormality resulting from acute exposure, however administered, is a necrosis of the corneal endothelium beginning in the basal portion of the cells, secondary swelling of the stroma, formation of excess basement membrane and thickening of Descemet's layer, and repair by sliding or stretching of the surviving endothelial cells.