Progestins and estrogens were found to increase lens permeability to cations in vitro but had no effect on active cation transport. It was dose related and dependent on the duration of exposure. The increase in cation permeability, determined by the rubidium 86 (86Rb) runout method, was accompanied by an increase in lens water, an alteration in cation content, and a loss of lens clarity.
Lambert BW. The Effects of Progestins and Estrogens on. Arch Ophthalmol. 1968;80(2):230-234. doi:10.1001/archopht.1968.00980050232017