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Article
August 1968

Experimental Allergic UveitisUveitis Following Immunization to Homologous and Heterologous Uveal and Retinovitreous Preparations

Author Affiliations

San Francisco
From the Eye Research Laboratories, Department of Ophthalmology, and Clinical Laboratories, San Francisco General Hospital, University of California Medical Center, San Francisco.

Arch Ophthalmol. 1968;80(2):235-242. doi:10.1001/archopht.1968.00980050237018
Abstract

Experimental uveitis has been produced in the rabbit and guinea pig following immunization to homologous uveal or retinovitreous extracts in complete Freund's adjuvant. The inflammation is markedly more severe in the guinea pig than in the rabbit. Circulating uveal antibody occurs concomitantly with disease in many animals. Neither clinical nor histologic inflammation was produced following immunization to heterologous uveal or retinovitreous antigen although circulating uveal antibody was present.

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