Using the Fluorescent Antibody Darkfield (FADF) method, the aqueous humor of 36 patients was examined for treponemes. Each patient had one or more of the following conditions: chronic uveitis, chorioretinitis, interstitial keratitis, dislocated lenses, optic atrophy, or neurosyphilis. Treatment with ampicillin and probenecid was instituted in seven of 12 patients whose aqueous humor contained organisms resembling Treponemapallidum. The most significant response to treatment was seen among six patients with active uveitis. Five of these patients had initial resolution of uveitis with dissappearance of intraocular treponemes. Two of these five patients subsequently developed recurrent uveitis concomittant with reappearance of intraocular treponemes. One patient had persistent uveitis and intraocular treponemes despite therapy.
Christman EH, Hamilton RW, Heaton CL, Hoffmeyer IM. Intraocular Treponemes. Arch Ophthalmol. 1968;80(3):303-307. doi:10.1001/archopht.1968.00980050305002