Intranuclear deposition of urate crystals was demonstrated in the corneal epithelium of a patient with gout. The crystals were either hexagonal, octagonal, or cylindrical in shape and were composed of a regular lattice structure. Factors such as pH, temperature, avascularity, and increased purine metabolism, which affect the precipitation of urate crystals, are discussed in relation to the corneal epithelium.
Slansky HH, Kuwabara T. Intranuclear Urate Crystals in Corneal Epithelium. Arch Ophthalmol. 1968;80(3):338-344. doi:10.1001/archopht.1968.00980050340008