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October 1968

Eleven-CIS Vitamin A in the Treatment of Retinitis PigmentosaA Negative Study

Author Affiliations

Brooklyn, NY
From the Division of Ophthalmology, Department of Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY.

Arch Ophthalmol. 1968;80(4):417-419. doi:10.1001/archopht.1968.00980050419001

Previous studies demonstrated that the 11-cis isomer of vitamin A prevented retinal rod degeneration in rats. Uncontrolled human studies suggested that 11-cis vitamin A given intramuscularly benefited patients with retinitis pigmentosa. A long-term rigidly controlled study was performed to determine whether or not 11-cis vitamin A may be of value in the treatment of retinitis pigmentosa. Final results were negative.