Ocular manifestations of aplastic anemia have infrequently been documented since Ehrlich's original description in 1888. In the case we have reported, the ocular abnormalities were confined to the retina and vitreous. Hemorrhage into the retina extended internally resulting in a separation between the internal limiting membrane and nerve fiber layer. This massive hematoma beneath the internal limiting membrane was misinterpreted clinically as a hemorrhagic detachment of the retina.
The accumulation of fibrin within superficial retinal hemorrhage was the histological basis of the clinically observed Roth's spots.
The ocular manifestations appeared late in the course of this patient's disease probably as a consequence of her depressed hematologic condition.
Wong VG, Bodey GP. Hemorrhagic Retinoschisis Due to Aplastic Anemia. Arch Ophthalmol. 1968;80(4):433-435. doi:10.1001/archopht.1968.00980050435005