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October 1968

Hemorrhagic Retinoschisis Due to Aplastic Anemia

Author Affiliations

Bethesda, Md
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, and the Medicine Branch, National Cancer Institute, National Institutes of Health, Public Health Service, US Department of Health, Education, and Welfare, Bethesda, Md. Dr. Bodey is presently at University of Texas, M. D. Anderson Hospital and Tumor Institute, Houston.

Arch Ophthalmol. 1968;80(4):433-435. doi:10.1001/archopht.1968.00980050435005

Ocular manifestations of aplastic anemia have infrequently been documented since Ehrlich's original description in 1888. In the case we have reported, the ocular abnormalities were confined to the retina and vitreous. Hemorrhage into the retina extended internally resulting in a separation between the internal limiting membrane and nerve fiber layer. This massive hematoma beneath the internal limiting membrane was misinterpreted clinically as a hemorrhagic detachment of the retina.

The accumulation of fibrin within superficial retinal hemorrhage was the histological basis of the clinically observed Roth's spots.

The ocular manifestations appeared late in the course of this patient's disease probably as a consequence of her depressed hematologic condition.