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October 1968

Collagenolytic Activity in Bovine Corneal Epithelium

Author Affiliations

From the Department of Cornea Research, Institute of Biological and Medical Sciences, Retina Foundation, Boston.

Arch Ophthalmol. 1968;80(4):496-498. doi:10.1001/archopht.1968.00980050498018

Collagenolytic activity was found in bovine corneal epithelium using a synthetic substrate. Increased levels were found after physical disruption of the epithelial cells. This activity was inhibited by disodium ethylene diamine tetraacetate. The release of a collagenolytic enzyme from traumatized epithelial cells may be of clinical importance in the pathogenesis of corneal stromal ulcerations.