Collagenolytic activity was found in bovine corneal epithelium using a synthetic substrate. Increased levels were found after physical disruption of the epithelial cells. This activity was inhibited by disodium ethylene diamine tetraacetate. The release of a collagenolytic enzyme from traumatized epithelial cells may be of clinical importance in the pathogenesis of corneal stromal ulcerations.
Slansky HH, Freeman MI, Itoi M. Collagenolytic Activity in Bovine Corneal Epithelium. Arch Ophthalmol. 1968;80(4):496-498. doi:10.1001/archopht.1968.00980050498018