The purpose of this study was to determine whether retrobulbar depot-corticosteroid can penetrate and persist in monkey ocular tissue. In comparison with systemic administration it was found that after retrobulbar administration, high concentrations do penetrate into the posterior uvea, and lower concentrations persist. Steroid also concentrated in the optic nerve after retrobulbar administration; whereas, there was no detectable steroid after systemic administration. Although no steroid was present in other ocular tissues after systemic administration, significant concentrations were found in the lens and vitreous when assayed after two and nine days. This concentration in the lens might be important in cataractogenesis.
Hyndiuk RA, Reagan MG. Radioactive Depot-Corticosteroid Penetration into Monkey Ocular TissueI. Retrobulbar and Systemic Administration. Arch Ophthalmol. 1968;80(4):499-503. doi:10.1001/archopht.1968.00980050501019