Fluorescein angiographic findings in patients with loss of central vision secondary to diabetic retinal microangiopathy are described. The development of microaneurysms and alterations in capillary permeability are the earliest angiographic alterations in the diabetic retina. Loss of macular function in diabetes is often associated with angiographic evidence of extensive intraretinal serous exudation in the macular region. Partial loss of the perifoveal capillary bed, retinal hemorrhage, and distortion of the retina by preretinal membrane formation are other causes of macular dysfunction in these patients.
Gass JDM. A Fluorescein Angiographic Study of Macular Dysfunction Secondary to Retinal Vascular DiseaseIV. Diabetic Retinal Angiopathy. Arch Ophthalmol. 1968;80(5):583-591. doi:10.1001/archopht.1968.00980050585004