Needle aspiration of orbital fluid in a patient with malignant (progressive) endocrine exophthalmos and generalized myasthenia gravis resulted in immediate regression of the proptosis and the chemosis, obviated the need for decompression, and permitted tarsorrhaphy. Biochemical studies on the orbital fluid showed it not to be a true transudate.
Haddad HM. Needle Aspiration of Malignant (Progressive) Endocrine Exophthalmos. Arch Ophthalmol. 1968;80(6):703-704. doi:10.1001/archopht.1968.00980050705003