[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
January 1969

Evolution of the Cryogenic Chorioretinal Lesion

Author Affiliations

From the Retina Service of the Massachusetts Eye and Ear Infirmary and Howe Laboratory of Ophthalmology, Harvard University Medical School, Boston. Dr. Amoils is permanently at 1202 Medical Arts Bldg, 220 Jeppe St, Johannesburg, South Africa. Dr. Haining's present address is Department of Ophthalmology, The University Dundee, 10 Dudhope Terrace, Dundee, Scotland.

Arch Ophthalmol. 1969;81(1):11-21. doi:10.1001/archopht.1969.00990010013003

By means of intravenously administered fluorescein, dynamic vascular changes can be demonstrated in the choroid and retina immediately after freezing. The fluorescein leakage, which has a characteristic pattern, ceases after 72 hours due to the cessation of active choriocapillary circulation. The color photographs illustrate the development of edema, evolution of pigmentation, and changes in the choroidal circulation after cryopexy. The rapid sequence color photographs taken before, during, and after freezing show the circulation to be stopped by probe pressure prior to freezing. They also demonstrate the return of circulation in the choroidal vessels of all sizes after thawing. Histology confirms the retinal edema, necrosis, and pigmentary changes as well as the vascular changes in the choroid and resultant subretinal exudation.