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March 1969

Intraocular Penetration of CephaloridineObservations in Experimental Animal and Human Eyes

Author Affiliations

From the Division of Ophthalmology, University of Colorado Medical Center, Denver.

Arch Ophthalmol. 1969;81(3):331-335. doi:10.1001/archopht.1969.00990010333006

Cephaloridine is a new wide-spectrum antibiotic. Following intravenous injection, useful antibiotic titers were found in the primary aqueous humor of rabbits. Much higher levels were present in secondary aqueous humor and following subconjunctival injection. Patients undergoing routine intraocular surgery were divided into several groups. The entire primary aqueous humor content of each anterior chamber was aspirated. A 1.0-gm intravenous dose of cephaloridine was then given, and secondary aqueous humor was withdrawn at intervals of time ranging from 15 minutes to eight hours. Extremely high antibiotic levels were present in the secondary aqueous humor of every patient; high titers were still present eight hours following a single intravenous cephaloridine injection.