[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.211.179.232. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
March 1969

Hereditary Optic AtrophyAn Autosomal Dominant With Incomplete Penetrance

Author Affiliations

New York
From the departments of pediatrics, Division of Medical Genetics (Drs. Shapiro and Hirschhorn) and ophthalmology (Drs. Raab and Leopold), Mount Sinai School of Medicine, New York.

Arch Ophthalmol. 1969;81(3):359-362. doi:10.1001/archopht.1969.00990010361011
Abstract

A 5-year-old child was examined because of decreased vision with as yet no detectable objective explanation. The mother and grandmother were known to have decreased vision and pallor of the optic nerve heads. Other presumed affected members of the maternal family were identified through five generations. Evaluation of the pedigree indicated an autosomal dominant heredity with incomplete penetrance, which is confirmed by segregation analysis. This mode of inheritance has not yet been described with regard to optic atrophy.

×