Quantitative ultrasonography is an ultrasonic examination in which the strength of echoes returned from various normal structures and pathological tissue is measured in relation to a fixed standard. Experience in over 350 patients has shown that the additional information obtained by analyzing echo strength as an indication of tissue density is of substantial value in the process of differential diagnosis. It is emphasized, however, that quantitative ultrasonography is not a direct test of the histological nature of a lesion and that, for this reason, the method must be used with an understanding of the principles on which it is based.
Bronson NR. Quantitative Ultrasonography. Arch Ophthalmol. 1969;81(4):460–472. doi:10.1001/archopht.1969.00990010462003