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April 1969

Cycloplegic Provocative TestingEffect of Miotic Therapy

Author Affiliations

New York
From the Department of Ophthalmology, New York Medical College, New York.

Arch Ophthalmol. 1969;81(4):544-547. doi:10.1001/archopht.1969.00990010546014

Cycloplegic agents may cause elevation of intraocular pressure in certain eyes without angle closure. Significant pressure increments occur in treated and untreated open angle glaucoma patients but are rarely noted in normal patients. Roughly one third of miotic-treated patients with open angle glaucoma studied by the authors are cycloplegic responsive. In approximately 50% of these patients the response represents a competitive inhibition of the miotic by the cycloplegic. In the remainder, a direct effect on ciliary muscle is possible.