Subconjunctivally injected hyaluronidase produced an increase of the corneal curvature accompanied by a corresponding increase of the total ocular refraction up to three diopters in 20 phakic and four aphakic eyes. The change started five to six days after the injection, reached its maximum after about ten days, and lasted for several weeks. No relationship was found between the change in refraction and the change in the ocular fluid dynamics. The possible role of the hyaluronidase sensitive mucopolysaccharides of the cornea and sclera in the realization of the phenomenon is discussed.
Treister G, Romano A, Stein R. The Effect of Subconjunctivally Injected Hyaluronidase on Corneal Refraction. Arch Ophthalmol. 1969;81(5):645-649. doi:10.1001/archopht.1969.00990010647008