Limbal wound histology was studied in 18 eyes obtained postmortem from five days to seven years after uneventful cataract extractions. Limbus-based flaps including Tenon's capsule appeared firmly sealed even in the five-day specimen. They provided significant early support to the slowly healing stromal wound. Stromal wounds were sealed by ingrowth of subepithelial connective tissue which had begun in the eight-day specimen and was complete in the 15-day specimen, but even then this wound was weak and easily disrupted. Stromal fibrocytes appeared inactive. Wound remodeling was first noted in the 46-day specimen and was complete in the 2½-year and later specimens. Endothelial repair was present in the eight-day and later specimens. Descemet's membrane appeared partially regenerated in three specimens years after surgery. Clinical implications are discussed.
Flaxel JT, Swan KC. Limbal Wound Healing After Cataract ExtractionA Histologic Study. Arch Ophthalmol. 1969;81(5):653-659. doi:10.1001/archopht.1969.00990010655010