In each of 22 rabbits, wounds were made in both corneas, an inoculum of Pseudomonas aeruginosa was swabbed over the corneas, and previously fitted corneal contact lenses were inserted in the right eye. In all but three, which were treated with saline as controls, both eyes were treated identically with daily subconjunctival injections of sodium colistimethate for five days. The interval between inoculation and initial injection of sodium colistimethate was varied. Treatment started in 2 or in 12 hours prevented or reduced corneal damage. In most cases corneal scarring was less severe in the eyes fitted with contact lenses. Contact lenses may benefit corneal healing by splinting the cornea, by affording increased antibiotic effect to the lenscovered ulcer, or by altering the metabolic environment beneath the lens to the disadvantage of the causative organism.
Lawrence HM, Dyer JA, Karlson AG. Effect of Contact Lenses on Pseudomonas Ulcers in Rabbit Corneas. Arch Ophthalmol. 1969;81(6):843-848. doi:10.1001/archopht.1969.00990010845017