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August 1969

Bacterial Flora of the Conjunctiva and Lid MarginEffects of Parenteral Trisulfapyramidines and Topical Tetracycline and Erythromycin

Author Affiliations

San Francisco
From the Francis I. Proctor Foundation for Research in Ophthalmology, University of California San Francisco Medical Center, San Francisco. Dr. Olson is now with Ophthalmology Associates, Savannah, Ga.

Arch Ophthalmol. 1969;82(2):197-202. doi:10.1001/archopht.1969.00990020199009

Parenteral therapy with trisulfapyramidines (Triple Sulfas) for 21 days did not alter the bacterial flora of the conjunctiva and lid margin. Topical therapy with tetracycline and erythromycin for six weeks significantly reduced the isolation frequency of Staphylococcus albus, increased the number of S albus strains resistant to either drug, and increased the number of sterile cultures. It is apparent that prolonged administration of topically applied tetracycline and erythromycin can reduce the incidence of certain bacteria on conjunctiva and lid margin, but such treatment may promote growth of resistant, wild-type allele strains which populate the ecological niche created by the therapy. There was no tendency for gram-negative overgrowth to occur following treatment with the three drugs in this study.