This article reports the first known case of bilateral central retinal artery occlusion associated with homocystinuria. Vascular occlusion may well explain cases of optic atrophy and sclerotic vessels which have been reported in the past.
Wilson RS, Ruiz RS. Bilateral Central Retinal Artery Occlusion in HomocystinuriaA Case Report. Arch Ophthalmol. 1969;82(2):267-268. doi:10.1001/archopht.1969.00990020269025