This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
To the Editor.
—The editorial by Berson in the Archives (81:453 [April] 1969) presents an approach to the study of genetic-type disease, eg, retinitis pigmentosa, which has much merit.However, in my experience, numerous retinitis pigmentosa patients who have the disease maintain secrecy, so that evaluating their offspring would be a most difficult project to undertake.Nevertheless, if this could be done, 11-cis vitamin A or 11-cis retinene (which is now available) should be given a trial.In reviewing the results of my study using 11-cis vitamin A in the treatment of retinitis pigmentosa, a brother and sister under the age of 10 were treated, one received 11-cis vitamin A and the other all-trans vitamin A. The one given 11-cis vitamin A improved, the other given all-trans vitamin A regressed.Of course, this is statistically insignificant, but perhaps encouragement enough for someone in the field to pursue Dr. Berson's
Chatzinoff A. COMMENTS ON RETINITIS PIGMENTOSA. Arch Ophthalmol. 1969;82(2):295. doi:10.1001/archopht.1969.00990020297031