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To the Editor.
—I have been asked to comment on spontaneous regression of retinoblastoma.We have seen a fair number of spontaneous regressions and they all present several typical features. The calcification seen in these children is probably not totally calcium, but is precipitated deoxyribonucleic acid which later binds calcium to produce a radiopaque complex. Other old hemorrhagic and inflammatory conditions in the eye may become secondarily calcified but never present the appearance seen in this youngster. In our tumor clinic we see a great many other associated conditions of the fundus and I cannot really imagine that Dr. Rubin's case could be anything but a spontaneous regression of retinoblastoma. Calcification of this type and the presence of abnormal blood vessels which appear to be neither part of the retinal nor of the choroidal circulation are the hallmarks of spontaneous regressions.The factors responsible for regression are certainly not always
Ellsworth RM. ADDITIONAL COMMENTS ON SPONTANEOUS REGRESSION OF RETINOBLASTOMA. Arch Ophthalmol. 1969;82(2):298. doi:10.1001/archopht.1969.00990020300037