The weight of the rabbit vitreous body is reduced by average clinical doses of hyperosmolar agents. The weight change is 2.7% with orally administered glycerol, and 3.7% and 3.9% with intravenously administered urea and mannitol respectively. This study substantiates the clinical observation that vitreous volume can be reduced by osmotic therapy.
Robbins R, Galin MA. Effect of Osmotic Agents on the Vitreous Body. Arch Ophthalmol. 1969;82(5):694-699. doi:10.1001/archopht.1969.00990020688019